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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
THOC2
All Species:
22.73
Human Site:
S1178
Identified Species:
38.46
UniProt:
Q8NI27
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NI27
NP_001075019.1
1593
182775
S1178
G
Q
L
K
S
R
K
S
Y
M
I
P
E
N
E
Chimpanzee
Pan troglodytes
XP_001139291
1595
183045
S1180
G
Q
L
K
S
R
K
S
Y
M
I
P
E
N
E
Rhesus Macaque
Macaca mulatta
XP_001086217
1593
182783
S1178
G
Q
L
K
S
R
K
S
Y
M
I
P
E
N
E
Dog
Lupus familis
XP_538164
1593
182721
S1178
G
Q
L
K
S
R
K
S
Y
M
I
P
E
N
E
Cat
Felis silvestris
Mouse
Mus musculus
B1AZI6
1594
182755
S1178
G
Q
L
K
S
R
K
S
H
M
I
P
E
N
E
Rat
Rattus norvegicus
XP_233081
1594
182711
S1178
G
Q
L
K
S
R
K
S
H
M
I
P
E
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510761
1648
188085
P1229
G
Q
L
K
S
R
K
P
Y
M
V
P
E
N
E
Chicken
Gallus gallus
XP_420332
1593
182430
P1175
G
Q
L
K
S
R
K
P
F
M
I
P
E
N
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001003847
1504
172218
A1124
K
V
L
N
L
G
Q
A
L
E
C
R
V
H
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_722763
1641
188490
P1245
G
Q
L
K
L
K
T
P
H
M
L
K
E
S
V
Honey Bee
Apis mellifera
XP_393587
1354
156054
A976
C
T
F
T
T
V
D
A
M
Y
C
A
K
F
V
Nematode Worm
Caenorhab. elegans
NP_498392
1437
164369
R1031
I
L
L
C
T
V
Q
R
W
H
S
E
K
E
V
Sea Urchin
Strong. purpuratus
XP_795489
1592
178912
Q1174
G
Q
L
K
A
R
K
Q
H
M
I
P
E
D
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_173871
1804
205705
P1211
A
A
L
S
A
R
K
P
H
W
V
T
D
E
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
99.9
99
N.A.
97.4
97.4
N.A.
85.8
88.1
N.A.
72.9
N.A.
39.7
43.1
29.5
48.7
Protein Similarity:
100
99.3
100
99.3
N.A.
98.9
99
N.A.
91.4
93.9
N.A.
83.4
N.A.
59
60.2
48.5
65.1
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
86.6
86.6
N.A.
6.6
N.A.
40
0
6.6
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
N.A.
33.3
N.A.
66.6
20
33.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
15
0
0
15
0
0
0
8
0
0
0
% A
% Cys:
8
0
0
8
0
0
0
0
0
0
15
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
0
0
0
0
0
8
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
0
8
72
15
65
% E
% Phe:
0
0
8
0
0
0
0
0
8
0
0
0
0
8
0
% F
% Gly:
72
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
36
8
0
0
0
8
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
58
0
0
0
0
% I
% Lys:
8
0
0
72
0
8
72
0
0
0
0
8
15
0
15
% K
% Leu:
0
8
93
0
15
0
0
0
8
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
72
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
0
0
0
58
0
% N
% Pro:
0
0
0
0
0
0
0
29
0
0
0
65
0
0
0
% P
% Gln:
0
72
0
0
0
0
15
8
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
72
0
8
0
0
0
8
0
0
0
% R
% Ser:
0
0
0
8
58
0
0
43
0
0
8
0
0
8
0
% S
% Thr:
0
8
0
8
15
0
8
0
0
0
0
8
0
0
0
% T
% Val:
0
8
0
0
0
15
0
0
0
0
15
0
8
0
22
% V
% Trp:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
36
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _